Derivatization reagents for GC

In gas chromatography, the volatility of compounds plays a major role. You can improve the volatility and get a better thermal stability for your analytes with our high purity derivatization reagents. Also a lower limit of detection in gas chromatography applications can be achieved.

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Derivatization is one of the most common ways to prepare compounds for GC that are otherwise difficult to separate. Through derivatization, it is possible to improve the separation by replacing active hydrogens from the analyte with various groups that are easier to handle.

Derivatization reagents for GC

Derivatization is one of the most common ways to prepare compounds for GC that are otherwise difficult to separate. Through derivatization, it is possible to improve the separation by replacing active hydrogens from the analyte with various groups that are easier to handle.

There are many reagents in use today for derivatization. There are three categories they can be allocated to:

  • Silylation
  • Acylation
  • Alkylation (Methylation)

Quality and support

  • Our derivatization reagents meet the highest demands of purity.

Helpful information at chromatography PDF downloads (service)

  • Selection guide for derivatization of important functional groups in GC
  • Derivatization procedures
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Purpose of derivatization

  • Improved volatility, better thermal stability or a lower limit of detection in gas chromatography
  • Prerequisite: quantitative, rapid and reproducible formation of only one derivative
  • Halogen atoms introduced by derivatization (e.g., trifluoroacetates) for specific detection (ECD) with the advantage of high sensitivity
  • Influence of elution orders and fragmentation patterns in MS by a specific derivatization

Important notes

Due to their purpose, derivatization reagents are very reactive chemicals. For this reason, they should be stored cool and protected from moisture. For easy access with a syringe, our derivatization reagents are supplied in vials with crimp caps. Vials with pierced sealing disks have limited stability and should be used up soon.

These products contain harmful chemicals which must be specially labeled as hazardous. For detailed information please see SDS.

Portfolio of derivatization reagents

Silylation reagents

BSA, DMCS, HMDS, TMCS, TSIM, MSHFBA, MSTFA, MBDSTFA and various silyl-mixes

Acylation reagents

HFBA, MBTFA, MBHFBA, PFBC, TFAA

Alkylation reagents

DMF-DMA, TMSH

 

Good to know
  • All derivatization reagents are supplied in crimp vials.
  • Additional for 1 x 10 mL, 1 x 50 mL and 6 x 50 mL can also supplied as screw neck vial (only on request – not part of standard product portfolio)
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