Advantages of QuEChERS (“Quick, Easy, Cheap, Effective, Rugged and Safe“ ) products in comparison with classical clean-up methods:Easy to handle and time-saving procedure as well as no need for glassware (convenient and economical). Low consumption of solvents and no need for chlorinated solvents (environmentally friendly). Broad range of pesticides can be detected and rugged method with high and safe recovery rates (reliable and good performance). These are the demands of modern sample preparation. The QuEChERS (pronounced as “catchers”) method, introduced by Anastassiades et al. in 2003, and the continuous development created an expansion of ready-to-use mixtures. QuEChERS became the method of choice in sample preparation for the analysis of pesticides and drugs in fruit, vegetables and other matrices.