Calibration Curve for ICP-MS Analysis

Excellent question. In general I do not trust calibration curves. For ICP-MS, I do standard additions and I do not force 0 through 0, but rather I subtract the blank from the sample and sample + spike signals. However, there are different types of blanks:

• Reagent blank, where the blank signal shows in all samples and standard solutions.
• Preparation blank, where the blank is from the sample preparation process only and not present in the calibration solution/standards.
• Background interference that may appear to be a blank; mass scans are generally required along with some investigative work to identify.
• Random contamination blanks that appear for elements like Ca, Fe, Na, Mg and Zn (the most troubling elements in my case).

I, like you and many analysts, find the blank issue to be more than a little complicated.

Serving you in chemistry,
Paul R. Gaines, Ph.D.
CEO of Inorganic Ventures

DISCLAIMER: Advice offered by the chemists at Inorganic Ventures is intended for the individual posing the question.