Method Detection Determining a Method Detection Limit when the blank value is contaminated with the analyte

The MDL is based on a method's ability to determine an analyte in a sample matrix, regardless of its source of origin. This is based on the variance for the analysis of samples. At least 3 levels are analyzed about 10 times each and the standard deviations of the results are estimated. These standard deviations are plotted to obtain a s0 extrapolated. The MDL at 95% confidence is defined as 3 x S0. If your blanks are as precise as indicated then the MDL will still be pretty low. However, if there is a high degree of variability in the blank then this approach will point this out.

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Paul R. Gaines, Ph.D.
CEO of Inorganic Ventures

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