For any syringe pump, the key to achieving the most accurate dispenses is eliminating all air from the fluid path. Traditional syringes trap approximately 50 µL of air between the tip of the syringe and the valve. For small syringes, this trapped air is the last to leave the syringe and the first to be drawn back in, making them difficult if not impossible to prime.

The Bubble Free Prime (BFP) syringe has a conical plunger tip that extends through the threaded termination and into the valve. The unique design of this Hamilton syringe pump expels the air from the syringe and valve decreasing the number of priming cycles required.